Oxidative DNA damage and subclinical hypothyroidism in children with obesity

Abstract Background Obesity-related oxidation stress plays a key role in obesity complications; however, its relation to thyroid status is an area for further research. The study aimed assess function obese children and oxidative deoxyribonucleic acid (DNA) damage. Results Fifty 40 normal weight were included . Anthropometric measurement, lipid profile, function, anti-thyroglobulin antibody, peroxidase 8-hydroxydeoxyguanosine serum level as marker of DNA damage measured. Thirty-six percent with have subclinical hypothyroidism. Central but not profile was significantly associated Waist circumference > 97th centile increases the risk hypothyroidism (odd ratio 10.82; confidence interval 95% 2.75–42.409; p -value<0.001). Conclusion represents factor children. Oxidation did show significant association